Rafael Lorente de Nó, born in Zaragoza, Spain, on the 8th of April, 1902, died in Tucson, USA, at the age of 88. His long and intensive scientific activity granted him the recognition of being one of the top neuroanatomists of the first half of the century and the founder of modern neurophysiology. He was the youngest pupil of Cajal, to whom he owed his outstanding skill in nervous system histological techniques and his deep knowledge of the structure of the central nervous system.